α-Arbutin

Basic Information of White Crystalline Arbutin Powder for sale:

Arbutin: Overview, Types, and Regulatory Standards

1.Arbutin Overview

Arbutin is a glycoside that naturally occurs in various green plants such as wheat, pears, and Ericaceae family plants (e.g., bearberry). It is often used in skincare products for its whitening effects, as it inhibits the activity of tyrosinase, an enzyme crucial to melanin synthesis.

2.Types of Arbutin

Arbutin has three main forms: α-arbutin, β-arbutin, and deoxyarbutin (D-arbutin):

α-Arbutin: The epimer of β-arbutin, differing in the spatial orientation of its glycosidic bond, which gives it around ten times the whitening efficacy of β-arbutin.

β-Arbutin: Though less effective in whitening than α-arbutin, β-arbutin is also widely used in skincare for its tyrosinase-inhibiting properties.

Deoxyarbutin: Has higher biological activity than both α- and β-arbutin, but is less favored due to its instability and potential risks. It can degrade into hydroquinone, a compound with significant health concerns.

3.Regulatory Standards and Safety

The regulatory status of arbutin and its derivatives varies by region:

China: α-Arbutin and β-arbutin are approved for cosmetic use, but deoxyarbutin is not included in the list of approved cosmetic raw materials due to safety concerns about hydroquinone formation.

Vietnam: Deoxyarbutin was banned in cosmetics as of July 2022.

European Union: Deoxyarbutin is prohibited in cosmetics (since July 2021) due to risks from hydroquinone formation.

In February 2023, the EU’s Scientific Committee on Consumer Safety (SCCS) established guidelines for the safe concentration of arbutin in cosmetics:

α-Arbutin: Maximum of 2% in facial creams and 0.5% in body lotions.

β-Arbutin: Maximum of 7% in facial creams.

Additionally, products containing α- or β-arbutin should maintain hydroquinone at the lowest possible levels, ideally no more than the trace levels naturally present in arbutins.

Effects of Alpha-Arbutin Powder for sale:

1. Whitening and Spot Reduction of alpha-arbutin powder

The whitening effect of α-arbutin works through inhibition of tyrosinase, a key enzyme in melanin production. By competing for the binding site of dopa and directly binding to tyrosinase, α-arbutin effectively reduces the formation of dopa and dopaquinone. This process disrupts melanin synthesis, thereby lightening pigmentation and helping reduce dark spots.

(Zhou Moxi, Yan Yali, Jiang Chunpeng, Yang Shuqi, Zhang Ying. Advanced Research of Arbutin as a Whitening Functional Factor in Cosmetics [J]. Food and Nutrition Science, 2019,8 (1): 35-44.

2.Antioxidant and ROS Inhibition of alpha-arbutin powder

As an antioxidant and anti-inflammatory agent, α-arbutin can inhibit intracellular ROS activity and suppress pro-inflammatory genes like IL-1β and TNF-α. α-Arbutin also demonstrates free radical scavenging abilities, potentially neutralizing DPPH and ABTS radicals.

3.Anti-inflammatory Effects of alpha-arbutin powder

α-Arbutin promotes extracellular matrix (ECM) stability and boosts collagen production, while also reducing the expression of cellular inflammatory factors. This helps to maintain skin health and resilience.

(LIUXiaoting,WANGXinxuan, Research progress on the pharmacological action and mechanism of arbutin , Food and Fermentation Industries.2022,48(2):309-316.)

4.Radiation Protection Effects of alpha-arbutin powder

α-Arbutin exhibits significant radioprotective properties, effectively reducing radiation-induced damage, especially at doses of 50 mg/kg. This effect is likely due to its antioxidant properties and free radical scavenging activity, providing a protective barrier against radiation.

(LIUXiaoting,WANGXinxuan, Research progress on the pharmacological action and mechanism of arbutin , Food and Fermentation Industries.2022,48(2):309-316.)

Advantages of Viablife α-Arbutin:

1.Sustainable Biosynthetic Production

α-Arbutin can traditionally be prepared through plant extraction, plant cell culture, or synthetic methods. While β-arbutin has multiple preparation methods, α-arbutin typically requires a sugar transfer reaction involving specific microbial enzymes to combine one glucose molecule with hydroquinone. Viablife Biotech utilizes a proprietary biosynthetic process, incorporating renewable carbon sources, advanced strain screening, and automated technology, to produce high-quality, stable α-arbutin through biological fermentation.

2.Pure Appearance and Consistent Color

Viablife’s α-Arbutin is produced as a pure, snow-white powder with consistent color and uniformity, ensuring a high-quality appearance.

3.High Purity Alpha-Arbutin Powder

The biosynthetic production of Viablife α-Arbutin yields a product with high purity and minimal impurities, suitable for demanding applications in cosmetics and skincare.

4.Uniform Particle Size and Excellent Solubility

Viablife α-Arbutin is manufactured with a strictly controlled, uniform particle size, ensuring better fluidity and quick dissolution in formulations.